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All about (HIV) ADIS

AIDS, also known as acquired immune deficiency syndrome, is an immune deficiency disease caused by human immunodeficiency virus (HIV) infection. The diagnosis of HIV infection is an essential part of AIDS prevention and control. It is necessary to establish sensitive and practical detection methods for monitoring, diagnosis or blood screening, and controlling the prevalence of AIDS. this paper reviews the current situation and progress of HIV detection technology

Infection mechanism and sign of 1 h IV

After the HIV invades, it’s surface glycoprotein gp120, and cell surface receptor protein CD4 bind to the host cell with high affinity. gp120 interacts with the host cell surface auxiliary receptor to make the virus closer to the host cell membrane. gp41 produces a series of conformational changes, and its N-terminal fusion peptide fragments insert into the host cell membrane. Resulting in the final fusion of the virus envelope and the cell membrane, viral RNA enters the cell. After¬†

Within 10-14 days after infection, the level of viral RNA increased exponentially, then decreased and maintained at a stable level, and entered the asymptomatic phase of HIV. P24 antigen level develops with the development of viral RNA levels. It can appear in the acute infection stage, as an indirect marker of viral replication. However, due to the lack of sensitivity of detection methods, the detection time of p24 antigen is shorter than that of RNA. The period from HIV infection to the detection of HIV antibodies

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